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Let’s get this out of the way — Ellen Pompeo is leaving Grey’s Anatomy, and there’s nothing we can do about it. Sadly, we won’t be seeing her in season 20. Season 20? That’s a lot of seasons — but Grey’s Anatomy keeps it as fresh and fun (and chaotic) as ever.

But can the show go on without the character that started it all? We feel given the depth of the show, revolving sub-plots, and evolving character arcs, Grey’s Anatomy will do just fine.